Preparation of microspheres of losartan potassium using natural polymers method used. The objective of the present investigation is to formulate multiparticulate gastroretentive dosage form of nizatidine, a h2receptor antagonist widely prescribed in gastric ulcers, duodenal. The measured weight was divided by the total amount of drug and polymers which were used for the preparation of the microspheres to obtained percentage yield. Floating microspheres of cp were prepared by solvent evaporation technique using hydroxypropyl methylcellulose hpmc k4m and ethyl. Improved bioavailability through floating microspheres of lovastatin. Pdf formulation of floating microspheres of nizatidine. Microencapsulation techniques using ethyl acetate as a. Preparation of floating microspheres floating microspheres were prepared by ionotropic gelation method.
Floating microspheres 100 mg were orally administered in suspension form to the animals in group i and nonfloating microspheres were administered to group ii, followed by a sufficient volume of drinking water. Floating microspheres 100 mg were orally administered in suspension form to the animals in group i and nonfloating microspheres were administered to group ii, followed by a sufficient. Formulation, optimization and evaluation of floating microspheres of captopril. A controlledrelease system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation. The present study involves preparation and evaluation of floating microspheres of verapamil hydrochloride for improving the drug bioavailability by prolongation. The purpose of this study is to formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method. The objectives were preparation of floating microspheres of lovastatin by using pure polymers and blends of polymers, characterization and evaluation of the. Application and advancement of microsphere as controlled delivery system.
These are gastro retentive drug delivery dosage systems grdds based on noneffervescent approach. A drug excipients compatibility study was performed using ftir. Optimization of methods for the preparation of famotidine. Formulation and evaluation of gastroretentive floating. Development and evaluation of floating microspheres of verapamil.
Formulation development of floating microspheres of cefditoren. Accurately weighed drug and polymers in different ratios are dissolved in the solvents like ethanol and dichloromethane 1. Diagnostic microspheres, used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides. To this dispersion, desired polymer in different concentrations was mixed in suitable proportion and stirring is continued. Solvent evaporation method the sodium alginate microspheres were prepared by solvent evaporation. Preparation and evaluation of floating microspheres of. Weight of floating micr ospheres percentage yield x 100. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides.
Preparation and evaluation of calcium silicate based. Research paper preparation and characterization of serratiopeptidase containing microspheres j. Preparation of microspheres gated key process parameters that affected the characteristics of plga microspheres, such as their. The accumulation of the carrier at the target site allow them to deliver the drug locally. Both natural and synthetic polymers have been used to prepare floating microspheres. Formulation and invitro evaluation of mucoadhesive. Surface morphology of floating microspheres by scanning electron microscopy drug entrapment efficiency was found to be optimum 61. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation. Preparation and in vitro characterization of porous carrierbased. Accurately weighed amount of drug was dispersed uniformly in aqueous mucilage of sodium alginate with stirring. The recent developments of fdds including approaches to design singleunit and multipleunit floating systems, mechanism of floating microspheres, methods of preparation of hollow microsphere, list of polymers used in hollow microspheres. A well designed controlled drug delivery system can. Research paper preparation and characterization of.
The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pills and laminated films. The floating microspheres were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose. Chitosanbased floating microspheres of trimetazidin. Gastroretentive drug delivery system, microspheres, floating microspheres, lansoprazole. Preparation of omeprazole floating microspheres the floating micro spheres were prepared by solvent evaporation method. The prepared microspheres were collected and weighed from different formulations. A novel approach for gastro retention article pdf available in world journal of pharmacy and pharmaceutical sciences. Preparation of microsphere floating microsphere containing metformin hydrochloride was prepared using emulsion solvent diffusion technique19. The microspheres were prepared by nonaqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose hpmc k 15 m, ethyl. The present study deals with an attempt to develop hollow floating microspheres of clarithromycin for gastro retention using eudragit polymers prepared by emulsion solvent diffusion method. Preparation and in vitro characterization of porous. Mehta abstract consisting of i calcium silicate cs as porous carrier.
Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Eudragit s 100, rs 100, rl 100, l 100 and l 100 55 were used to prepare hollow microspheres. Development and evaluation of hollow microspheres of. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation before the drug is incorporated. Preparation of floating microspheres of dextromethorphan hbr floating microsphere of dxm hbr was prepared by emulsion solvent evaporation technique.
Application and advancement of microsphere as controlled. General method for preparation of floating microspheres floating microspheres containing ofloxacin hydrochloride were prepared by an emulsification solvent evaporation technique soppimath et al. Preparation and characterization of gastroretentive. Floating drug delivery systems fddss are expected to remain buoyant in a lasting way upon the gastric contents. Floating microspheres were prepared by solvent evaporation method using distilled water as continuous phase. Hollow microsphere promises to be a potential approach for gastric retention. The main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique. Preparation of polylactidecoglycolide microspheres and. Preparation and evaluation of calcium silicate based floating microspheres of amoxicillin m. Development and characterization of floating microspheres of esomeprazole magnesium trihydrate by solvent evaporation method html full text. This organic phase was added slowly to 100 ml of 1. The drug and polymer in different proportions are weighed, the polymer was codissolved into previously cooled mixture of ethanol. The drug to polymer ratio was used to prepare the different formulation.
The objective of present study was to prepare floating microspheres of azithromycin to improve its bioavailability by increasing residence time in the stomach 4. Of microspheres theoretical wgt to be preparedloading 100 x actual amt. During the preparation of microspheres or after the formation of microspheres by incubating. The aim of present study involves preparation and characterization of floating microspheres using trimetazidin dihydrochloride as a model drug to increase the residence time in the stomach without contact with the mucosa, floating microspheres. Preparation of eudragit e100 microspheres by modified solvent evaporation method vandana singh 1 and amrendra kumar chaudhary2 1translam institute of. The polymer content was a mixture of eudragit rs 100 hydroxypropylmethylcellulose hpmc k4m. The effect of various formulation variables on the size and drug release was investigated.
1529 683 586 1175 424 882 166 931 1370 886 95 1024 1262 1258 795 1024 933 237 494 1512 262 352 1185 1224 397 642 1390 721 1028 882 1371 246 822 1164 208 1047 1186